The 308 nm excimer laser is a widely used device throughout the field of dermatology for many diseases, including psoriasis, vitiligo, hypopigmented disorders, alopecia areata, atopic dermatitis, and many other dermatologic diseases such as cutaneous T-cell lymphoma, other lymphoproliferative disorders, granuloma annulare, Langerhans cell histiocytosis, lichen planus, and localized scleroderma.1,2 The term excimer is derived from “excited dimer,” which describes the mixture of the noble gas xenon and the halogen chloride gas (XeCl) that is utilized. The dissociation of these exciting dimers produces a 308 nm ultraviolet (UV) monochromatic coherent wavelength, which lies within the UVB spectrum.1,3 Although the excimer laser can be used in the treatment of many dermatologic conditions, this study will focus on the treatment of psoriasis. Psoriasis is a chronic, inflammatory disease that primarily manifests with cutaneous findings and affects ~3% of the American population.4 The current understanding of the pathogenesis and pathophysiology of psoriasis is continuing to evolve, but the majority of knowledge surrounds the most classical variant, psoriasis vulgaris. Psoriasis Vulgaris compromises more than 80% of cases, usually presenting with raised, well-demarcated, erythematous oval plaques with an adherent silvery scale. It is a complex immune-mediated disease propagated by abnormal interactions between T lymphocytes, dendritic cells, keratinocytes, neutrophils, and proinflammatory cytokines.
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